The Red Skull has assembled an army of supervillains and other henchmen in a plot to take over the world. Along with battling generic enemies, players also face Klaw, the Living Laser, Whirlwind, The Sentinels, Wizard, the Grim Reaper, the Mandarin, The Juggernaut, Ultron, the assassin Crossbones, and finally the Red Skull himself.